技术平台 - 环码生物CirCode

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Leading Circular RNA Therapeutics.

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CircRNA Production Platform

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CirCode's proprietary circularization technology is based on the self-splicing activity of Group II intron ribozymes, allowing highly efficient circularization of any RNA in vitro. This technology features no scar sequence and low requirement, making it a robust and scalable option for industrial production.

Build on our circularization technology, CirCode has revolutionized the entire process of circular RNA production, achieving high effeiency, large scale with low cost.

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Sequence Design Platform

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Unlike linear mRNA, the translation of circRNA is initiated through the translation initiation elements in a cap-independent manner. The translation of circRNA is typically less efficient than mRNA. However, its translation is cell- or tissue-specific.

CirCode has developed a high-throughput circRNA-based screening system that efficiently screens translation initiation elements. With millions of sequences already screened, we have obtained a large number of translation initiation elements, providing excellent translation efficiency. Furthermore, an AI-based sequence design program has been established specifically for circRNA. This program generates circRNA sequences routinely with amino acid sequences, with amazing translation efficiency.

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